منابع مشابه
Cytoskeleton key
T he protein WHAMM serves as an intermediary between the microtubule and actin cytoskeletons. Shen et al. discover that binding to microtubules changes WHAMM’s interactions with actin, offering insight into how cells keep the two cytoskeletons in sync (1). Researchers have mainly studied the microtubule and actin cytoskeletons separately. For example, they’ve uncovered how actin dynamics shape ...
متن کاملBacteriophage Tubulins: Carrying Their Own Cytoskeleton Key
Cytoskeletal elements are well known to be widespread in eukaryotes and prokaryotes, providing important, diverse functions for cells large and small. Two new studies report that some bacteriophages encode their own tubulin homologs to facilitate phage reproduction within the host cell.
متن کاملXMAP215: a key component of the dynamic microtubule cytoskeleton.
Microtubules are essential for various cellular processes including cell division and intracellular organization. Their function depends on their ability to rearrange their distribution at different times and places. Microtubules are dynamic polymers and their behaviour is described as dynamic instability. Rearrangement of the microtubule cytoskeleton is made possible by proteins that modulate ...
متن کاملRhophilin-1 is a key regulator of the podocyte cytoskeleton and is essential for glomerular filtration.
Rhophilin-1 is a Rho GTPase-interacting protein, the biologic function of which is largely unknown. Here, we identify and describe the functional role of Rhophilin-1 as a novel podocyte-specific protein of the kidney glomerulus. Rhophilin-1 knockout mice were phenotypically normal at birth but developed albuminuria at about 2 weeks of age. Kidneys from severely albuminuric mice revealed widespr...
متن کاملRho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity
Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pul...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2012
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1991if